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In a 2-year carcinogenicity study in Sprague Dawley rats, subcutaneous doses of 0.0025, 0.01, 0.025 and 0.1 mg/kg/day were administered (below quantification, 0.8-, 1.8- and 11-fold the exposure at the MRHD)

However, continuous taking COCP might increase the risk of venous and arterial thrombosis and elevate C-reactive protein (CRP) levels which cause cardiovascular diseases [50]

But the same location in the peroxidase enzymes is blocked by the protein structure so that substrates can interact only with the heme edge

Treatment regimens and guidance: The British National Formulary (BNF) and NICE Clinical Knowledge Summaries outline treatment regimens for B12 deficiency